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Termination of pregnancy — medical
Mifepristone then misoprostol regimens by gestation.
Source: NICE NG140Regimens
| Up to 10+0 wk | Mifepristone 200 mg, then misoprostol 800 micrograms vaginal 24–48 h later. |
|---|---|
| 10+1 to 23+6 wk | Mifepristone 200 mg, then misoprostol 800 micrograms vaginal 36–48 h later, then 400 micrograms every 3 h. |
| 24+0–25+0 wk | Misoprostol 400 micrograms every 3 h. |
| 25+1–28+0 wk | Misoprostol 200 micrograms every 4 h. |
| >28 wk | Misoprostol 100 micrograms every 6 h. |
Other points
- Surgical: doxycycline 100 mg BD 3 days prophylaxis
- Cervical priming to 13+6: misoprostol 400 micrograms sublingual 1 h or vaginal 3 h before
- Anti-D: offer after 10+0 weeks
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.