Early pregnancyFree in the app
Miscarriage — management
Expectant, medical or surgical — the woman chooses.
Source: NICE NG126 (2026)Options
| Expectant | First-line for 7–14 days. |
|---|---|
| Medical — missed | Mifepristone 200 mg oral, then misoprostol 800 micrograms (vaginal, oral or sublingual) 48 h later. |
| Medical — incomplete | Misoprostol 600 micrograms single dose (800 acceptable); no mifepristone. |
| Surgical | MVA under local anaesthetic as outpatient, or suction evacuation in theatre. |
Follow-up
- Urine pregnancy test 3 weeks after medical management
- Positive test: review for retained tissue, molar or ectopic pregnancy
Anti-D (2026 update)
| ≤11+6 weeks | Do not offer for miscarriage or ectopic. |
|---|---|
| 12+0–12+6 weeks | Offer ≥250 IU if RhD-negative with medical or surgical management. |
| Threatened | Consider at 12+0–12+6 if heavy or recurrent bleeding. |
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.