GynaePulse
Early pregnancyFree in the app

Pregnancy of unknown location

Positive test, no pregnancy seen on TVS.

Source: NICE NG126
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hCG 48 h apart

Rise >63%Likely developing IUP (ectopic not excluded) — TVS in 7–14 days, earlier if hCG ≥1500.
Fall >50%Likely failing — urine pregnancy test 14 days later; review within 24 h if positive.
In betweenClinical review in EPU within 24 hours.
Pain, heavy bleeding, shoulder-tip pain or collapse = urgent review regardless of hCG.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.