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Ovarian cancer — treatment

Complete removal of all visible disease matters most.

Source: ESGO 2023 · ESMO-ESGO 2024 · NICE TAs
Apparent earlyStaging: washings, TAH, BSO, omentectomy, peritoneal biopsies, pelvic and para-aortic nodes (appendix if mucinous).
AdvancedPrimary surgery aiming for no residual disease.
Not resectable or unfitBiopsy, then 3–4 cycles chemo, interval surgery, then complete 6 cycles.
ChemotherapyCarboplatin AUC 5–6 plus paclitaxel 175 mg/m² every 3 weeks for 6 cycles.
MaintenanceBRCA-mutated: olaparib 2 years. HRD-positive: olaparib plus bevacizumab. Any status: niraparib 3 years.
GeneticsGermline BRCA testing for all non-mucinous epithelial cancers.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.