Gynae oncologyFree in the app
Gestational trophoblastic neoplasia
FIGO 2000 anatomical stage + WHO prognostic score (e.g. “III:4”).
Source: FIGO 2000 · WHOStage
| I | Confined to uterus. |
|---|---|
| II | Genital structures outside uterus. |
| III | Lungs ± genital tract. |
| IV | Other distant sites (brain, liver…). |
WHO score items
| Age | <40 = 0; ≥40 = 1 |
|---|---|
| Antecedent | Mole 0; miscarriage 1; term 2 |
| Interval | <4 mo 0; 4–6 = 1; 7–12 = 2; >12 = 4 |
| hCG | <10³ 0; 10³–10⁴ 1; 10⁴–10⁵ 2; ≥10⁵ 4 |
| Tumour size | <3 cm 0; 3–4 cm 1; ≥5 cm 2 |
| Mets site | Lung 0; spleen/kidney 1; GI 2; liver/brain 4 |
| No. of mets | 0 = 0; 1–4 = 1; 5–8 = 2; >8 = 4 |
| Failed chemo | Single drug 2; ≥2 drugs 4 |
Risk
| ≤6 | Low risk — single-agent methotrexate (cure ~100%). |
|---|---|
| ≥7 | High risk — EMA/CO (cure ~94%). |
| ≥13 | Ultra-high risk. |
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.