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Misoprostol — FIGO dose chart

Misoprostol-only regimens by indication and weeks.

Source: FIGO misoprostol chart (2023) · RCOG GTG 55 (2025)

Missed miscarriageBelow 13 weeks800 µg vaginal, buccal or sublingual every 3 hours until it passes.

Incomplete miscarriageBelow 13 weeksSingle dose: 600 µg oral, 400 µg sublingual or 800 µg buccal.

Fetal death13–24 weeks400 µg every 3 hours.

Fetal death25–27 weeks200 µg every 4 hours.

Fetal death / induction28 weeks or more25–50 µg vaginally every 4 hours, or 50–100 µg orally every 2 hours.⚠ Not buccal or sublingual for a live baby (hyperstimulation).

Cervical priming13–24 weeks400 µg 1–2 hours before the procedure.

PPH preventionAfter birth600 µg orally once (where oxytocin is unavailable).

PPH treatmentAfter birth800 µg sublingually once.

Previous caesarean: safe before 28 weeks; not recommended from 28 weeks. Avoid the vaginal route with heavy bleeding.

A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.