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Anti-D & thromboprophylaxis

RhD-negative women and LMWH doses.

Source: BSH · NICE NG126 (2026) · RCOG 2026
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Anti-D

<12 weeksNot needed for miscarriage or ectopic (NICE 2026).
12+0–19+6≥250 IU IM within 72 h; no Kleihauer.
≥20 weeks≥500 IU + Kleihauer; more if fetal bleed is large.
RAADP1500 IU at 28–30 weeks, or 500 IU at 28 and 34 weeks.
After birth≥500 IU + Kleihauer if baby RhD-positive.

LMWH prophylaxis

<100 kgEnoxaparin 40 mg daily
100–129 kg60 mg daily
130–169 kg80 mg daily
≥170 kg0.6 mg/kg/day
Treatment dose: enoxaparin 1 mg/kg twice daily (booking weight) for rest of pregnancy and ≥6 weeks postnatal.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.