Drug dosesFree in the app
Hyperemesis drugs
Antiemetic ladder, thiamine and fluids.
Source: RCOG GTG 69 (2024) Calculator
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Cyclizine1st line50 mg oral, IM or IV 8-hourly.
Prochlorperazine1st line5–10 mg oral 6–8-hourly; 12.5 mg IM/IV 8-hourly.
Metoclopramide2nd line5–10 mg 8-hourly; max 30 mg/day.⚠ Extrapyramidal effects; not with phenothiazines.
Ondansetron2nd line4 mg oral 8-hourly or 8 mg 12-hourly; 8 mg IV over 15 min.⚠ Small cleft risk in 1st trimester — counsel, don’t withhold.
ThiamineAll admitted100 mg oral TDS, or IV Pabrinex, before any dextrose.⚠ Prevents Wernicke’s.
IV fluids: 0.9% saline with KCl guided by U&E — avoid dextrose. Consider LMWH.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.