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HIV in pregnancy

Viral load at 36 weeks decides the mode of birth.

Source: BHIVA 2025

Mode of birth by viral load (36 wk)

Below 50 copies/mlVaginal birth, including VBAC.
50–399Consider planned CS.
400 or morePlanned CS from 38 weeks.
  • Start antiretrovirals as early as possible; dolutegravir-based preferred.
  • IV zidovudine in labour or before CS if viral load above 1000, unknown or untreated.
  • Baby: post-exposure prophylaxis within 4 hours (zidovudine 2 weeks if low risk; triple therapy if high risk).
  • Feeding: formula in the UK; WHO supports exclusive breastfeeding when the mother is on ART with good adherence.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.