Medical disorders in pregnancyFree in the app
SLE and antiphospholipid syndrome
Keep the disease quiet and prevent clots.
Source: EULAR 2019 · ACR 2020SLE
- Continue hydroxychloroquine throughout — stopping it causes flares.
- Safe: prednisolone, azathioprine, tacrolimus, ciclosporin.
- Stop before conception: mycophenolate (6 weeks), methotrexate (1–3 months), cyclophosphamide.
- Aspirin 75–150 mg from 12 weeks.
- Flare vs pre-eclampsia: flare has low C3/C4, rising anti-dsDNA, active urine sediment.
- Anti-Ro/La: congenital heart block risk about 2%; fetal PR monitoring from 16 weeks.
APS
| Obstetric APS | Aspirin plus prophylactic LMWH through pregnancy and 6 weeks after birth. |
|---|---|
| Thrombotic APS | Therapeutic LMWH plus aspirin. Stop warfarin before 6 weeks. No DOACs. |
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.