Medical disorders in pregnancyFree in the app
Kidney disease and AKI
Pregnancy creatinine is normally 45–60 µmol/L.
Source: UK Kidney Association 2019 · KDIGOChronic kidney disease
- High risk for pre-eclampsia: aspirin from 12 weeks; BP target 135/85.
- Stop ACE inhibitors and ARBs once pregnant; enalapril is fine after birth and in breastfeeding.
- Creatinine above 125 µmol/L before pregnancy predicts loss of kidney function.
- Transplant: wait at least 1 year with stable function; mycophenolate to azathioprine.
AKI
| Definition | Creatinine rise of 26.5 µmol/L in 48 h, or 1.5 times baseline. |
|---|---|
| Causes | Pre-eclampsia/HELLP, sepsis, haemorrhage, AFLP, TTP, HUS, obstruction. |
| Do | Strict fluid balance, stop NSAIDs and nephrotoxics, treat the cause. |
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.