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Premenstrual syndrome

Diary first, then a stepped plan.

Source: RCOG GTG 48
DiagnosisProspective symptom diary for 2 cycles.
First lineExercise, CBT, vitamin B6; drospirenone pill; low-dose SSRI (luteal or continuous).
Second lineTransdermal oestradiol with progestogen protection; higher-dose SSRI.
Third lineGnRH analogue with add-back HRT.
Fourth lineHysterectomy and BSO with HRT, after a GnRH trial.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.