GynaePulse
GynaecologyFree in the app

Overactive bladder

Bladder training first, then drugs.

Source: NICE NG123 · TA290
SolifenacinAnticholinergic5–10 mg once daily.⚠ Review at 4 weeks.
Oxybutynin IRAnticholinergic2.5–5 mg two or three times a day.⚠ Not for frail older women.
MirabegronBeta-3 agonist50 mg daily (25 mg in kidney or liver impairment).⚠ Check BP; not in severe uncontrolled hypertension.
  • First: bladder training 6 weeks, reduce caffeine, vaginal oestrogen if atrophic.
  • Refractory: urodynamics, botulinum toxin 100 U (must accept self-catheterisation), tibial or sacral nerve stimulation.
  • Urodynamics are not needed before surgery for clear pure stress incontinence.
A summary for trained clinicians. Always check the full guideline, the patient in front of you and your hospital's protocol. Spotted an error? Tell us.